Gene Tweak Supercharges Hearing in Mice

Gene Tweak Supercharges Hearing in Mice

Researchers from Michigan Medicine’s Kresge Hearing Research Institute have discovered that altering the expression of the protein neurotrophin-3 (Ntf3) in mice can significantly improve auditory processing. The study, published in PLOS Biology, found that increasing the number of synapses in the mice led to better performance on auditory tests such as the GPIAS and Auditory Brainstem Response (ABR) tests. This suggests that the enhanced synaptic connections enable the mice to process more auditory information than normal.

The research indicates that boosting Ntf3 expression can not only improve hearing in middle-aged mice but also aid in recovering some hearing in mice with damaged inner ears. The increased synapses between hair cells in the cochlea and the brain allow for more efficient signal transmission and processing. These findings hold promise for developing new treatments for hearing disorders and other neurodegenerative conditions.

Summary

Other news in science